红花石蒜中的一个新石蒜生物碱(英文)

A new Amaryllidaceae alkaloid from the bulbs of Lycoris radiata

目的:研究红花石蒜中的石蒜生物碱。方法:采用多种层析柱分离手段,运用NMR和HR-ESI-MS等波谱技术鉴定化合物的结构。此外,生物碱110进行了流感甲型病毒的活性测试。结果:从红花石蒜中分离鉴定了1个新石蒜生物碱和9个已知的石蒜生物碱:2-methoxy-6-O-ethyloduline(1),2-methoxy-6-O-methyloduline(2),trispherine(3),8-O-demethylho-molycorine(4),homolycorine(5),9-O-demethylhomolycorine(6),oduline(7),lycorenine(8),6α-O-methyllycorenine(9)和O-ethyllycorenine(10)。结论:化合物1为新的高石蒜碱类型的石蒜生物碱,生物碱13为该植物中的主要成分,且对流感甲型病毒显示了较弱的抗病毒活性,IC50分别为2.06,0.69,2.71μgmL1,CC50分别为14.37,4.79,80.12μgmL1。

AIM： To study the Amaryllidaceae alkaloids of the bulbs of Lycoris radiata. METHODS： The chemical constituents were isolated and purified by various chromatographic techniques, and the chemical structures were elucidated on the basis of spectroscopic methods. In addition, the antiviral activities of alkaloids 1-10 were evaluated using flu virus A. RESULTS： One new homoly- corine-type alkaloid 2α-methoxy-6-O-ethyloduline （1）, together with nine known alkaloids 2o：-methoxy-6-O-methyloduline （2）, trispherine （3）, 8-O-demethylhomolycorine （4）, homolycorine （5）, 9-O-demethylhomolycorine （6）, oduline （7）, lycorenine （8）, 6α-O-methyllycorenine （9） and O-ethyllycorenine （10） were obtained. CONCLUSION： Alkaloid 1 is a new compound, and 1-3 were major alkaloids in this plant. Alkaloids 1-3 showed weak antiviral activities against flu virus A with IC50 values of 2.06, 0.69, and 2.71 μg.mL^-1 and CC50 values of 14.37, 4.79, and 80.12 μg.mL^-1, respectively.