运动与抗氧化研究的新进展

NEW ADVANCE OF RESEARCHES ON EXERCISE AND ANTIOXIDATION

运动引起组织氧耗的增加可导致自由基产生增加 ,当自由基数量超过体内抗氧化防御能力 ,可导致细胞生物分子的损伤。简要讨论了急性和慢性运动对于主要的抗氧化酶超氧化物歧化酶、谷胱甘肽过氧化物酶、过氧化氢酶以及非酶类抗氧化剂谷胱甘肽等抗氧化防御系统的影响 ,并综述了抗氧化剂在预防氧化应激中的作用。研究证实 ,运动训练可引起组织超氧化物歧化酶和谷胱甘肽过氧化物酶活性增强以及谷胱甘肽浓度增高 ;抗氧化剂的补充可预防和缓解运动性自由基损伤 。

It was well established that the exercise induced increase in oxygen consumption in tissues resulted in an increased production of free radicals and the failure to remove free radicals could lead to oxidative damage of cellular biomolecules.Not only effects of acute and chronic exercise on primary antioxidant enzymes including superoxide dismutase,glutathione peroxidase,catalase and an important nonenzymatic antioxidant—glutathione but also roles of antioxidants in the prevention of oxidative stress were reviewed.Growing evidences indicated that exercise training resulted in an elevation in the activities of both superoxide dismutase and glutathione peroxidase along with increased concentrations of glutathione in tissues.Supplements of antioxidants might prevent or mitigate exercise induced oxidative damage and reinforce antioxidant capacity.