LAP^+CD4^+T细胞的研究进展

Advances in the research of LAP^+CD4^+T cells

调节性T细胞是机体维持自身稳定的重要组成部分,对免疫反应具有抑制效应,在阻止自身免疫反应和维持机体免疫平衡等方面均具有重要作用。现在已发现不同的具有调节功能的T细胞亚群,如CD4+CD25+T细胞、Th3细胞和Tr1细胞等,这些T细胞多通过产生具有抑制功能的细胞因子,如IL-10和TGF-β等发挥免疫抑制效应。LAP+CD4+T细胞是近年发现的一种新的调节性T细胞亚群,在体内外实验中被证实具有免疫抑制作用,它通常以依赖TGF-β和IL-10等细胞因子的方式来发挥作用,且在一些疾病的动物模型中它影响着疾病的发生、发展,如自身免疫性疾病,炎症型疾病等。较少的研究提示LAP+CD4+T细胞在癌症病人中具有促进肿瘤进展的作用。

Having a suppressive effect on immune response , regulatory T cells （Tregs） play an important role in the maintenance of homeostasis. Treg cells are necessary both to maintain self- tolerance and prevent the onset of autoimmune disease. The Treg cells studied previously were mainly divided into three subpopulations ： CD4＋CD25＋T cells, Th3 cells and Tr1 cells. These T cells exert the immune suppressive function by producing some kinds of cytokines , such as IL-10 and TGF-β, with the ability of immune suppressive. Recently , LAP＋CD4＋T cells have been identified as a new subset of Treg cells and a population with regulatory function both in vitro and in vivo. This regulatory function is partly mediated by TGF-β and IL-10. In animal experiments , these cells have been shown to affect the genesis and development of some diseases , such as autoimmune disorder and inflammatory disease. A few researches implied that these cells also play an important role in tumor progression in patients with cancer.