Penta D、Penta E基因座与军人被动攻击行为关联的病例对照研究

Case-control study of association between Penta D,Penta E loci with passive aggressive behaviors of armymen

目的探讨军人被动攻击行为与Penta D、Penta E基因座的关联情况。方法采用PCR结合毛细管电泳的方法对178例男性军人被动攻击行为者(研究组)和459例健康男性(对照组)的外周静脉血样进行Penta D、Penta E基因座的基因型分析,观察两组在Penta D、Penta E基因座的等位基因及基因型分布差异。结果 Penta D、Penta E基因座均符合遗传平衡定律(Hardy-Weinberg定律);Penta E基因座等位基因及基因型频率在两个群体中分布差异有统计学意义(P<0.05);在两个群体中Penta E基因座的基因型16-18的频率分布差异有统计学意义(P<0.01,OR:6.564,95%CI:2.278～18.914);PentaD基因座等位基因频率及基因型频率在两个群体中分布无显著差异(P>0.05)。结论 Penta E基因座多态性与军人被动攻击行为的发生存在关联,Penta E基因座基因型16-18为军人被动攻击行为的遗传易感因素。

Objective To investigate the depth of anesthesia of propofol monitored by using narcotrend in no pain-anesthesia during colonoscopy,assessing its clinical safety,efficacy in order to establish the appropriate range of Narcotrend index（NI） in a painless colonoscopy,and serve as a clinical guidance.Methods One hundred fifty patients undergoing painless colonoscopy were enrolled.All patients were randomly divided into three groups according to NI with different dose of propofol infusion,there were fifty patients in each groups（Group A： NI = 35-45,Group B NI = 46-56,Group C NI = 57-67）.Record the vital signs,adverse reactions including cough,body movement,regurgitation,aspiration,and the operation time.The recovery time and the dose of propofol were also recorded.Results The patients in Group A had the longest time to wake up and consumed the largest dose of propofol（P 0.01）.With all the three groups,adverse reactions in Group B were only 8%,and were lower than that in Group A（24%） and Group C（16%）（P 0.05）.Conclusion Narcotrend can predict the depth of anesthesia in no pain-anesthesia during colonoscopy,with NI between 46 and 56 have more safety and efficacy.