醒脑静联合甲氯芬酯治疗脑外伤后持续植物状态的疗效观察

The Efficacy of the Meclofenoxate Treated with Xingnaojing in the Patients with the Persistent Vegetative State after TBI

目的观察醒脑静联合甲氯芬酯治疗脑外伤后持续植物状态的疗效。方法脑外伤后持续植物状态99例随机分为醒脑静联合甲氯芬酯组51例和对照组48例。对照组予常规治疗,醒脑静联合甲氯芬酯组在常规治疗基础上,予醒脑静及甲氯芬酯。结果醒脑静联合甲氯芬酯治疗3个月后的有效率及促醒率均明显高于对照组(P<0.05);治疗6个月后的好转率明显高于对照组(P<0.05),促醒率无显著差异;治疗6个月促醒时间明显短于对照组(P<0.05)。结论醒脑静联合甲氯芬酯治疗脑外伤后持续植物状态,可提高促醒率和好转率,缩短促醒时间,值得临床推广。

Objeetive To observe the efficacy of the Meclofenoxate treated with Xingnaojing in the patients with persistent vegetative state after TBI. Method 99 patients in persistent vegetative state after TBI was randomly divide into two groups. The control group： 48 patients treated with the basic treatment; and the treatment group： 51 patients treated with Meclofenoxate and Xingnaojing including the basic treatment. Result The rate of consciousness recovery and the efficiency in treatment group is obviously higher than the control group in 3 months treatment; the efficiency in treatment group is obviously better than the eontrol group and the waking time in the treatment group is shorter than control group in 6 months treatment. But there is no difference in the rate of consciousness recovery between the two groups in 6 months treatment. Conclusion Meclofenoxate treated with Xingnaojing is efficient in the treatment of persistent vegetative state after TBI.