氧自由基清除剂对脑梗死患者血清中TNF-α和IL-6动态变化趋势的影响

The Dynamic Changes of Serum Levels of TNF-α and IL-6 in Cerebral Infarction Patient Treated with Oxygen Free Radical Scavenger

目的动态观察运用氧自由基清除剂(依达拉奉)对脑梗死发病后1个月内血清中TNF-α和IL-6的含量的变化趋势。方法选择急性脑梗死患者64例,随机分为阳性对照组32例和治疗组32例,并与30例正常体检者作为正常对照(阴性对照组);阳性对照组采用常规治疗,治疗组加用依达拉奉30mg静脉滴注,2次/d,疗程14d;检测发病后12h、24h、48h、72h、7d、14d、30d血清中TNF-α和IL-6含量,并在1个月后进行神经功能缺损评分。结果急性脑梗死患者不同时期血清TNF-α和IL-6水平比较,72h最高,而恢复正常时间且有明显差异(治疗组vs阳性对照组=14d vs 30d),且治疗组TNF-α和IL-6水平较对照组在14d有明显下降(P<0.05)。结论依达拉奉通过清除自由基减少炎症的发生,缩短炎症的时间,有利于神经功能的恢复。

Objectives To observe the dynamic changes of serum levels of TNF-α and IL-6 in patients who happened cerebral infarction in one month treated with oxygen free radical scavenger, Edaravone. Method 64 cases of acute cerebral infarction patients were randomized into treated group （32 cases） and positive control group （32 cases）. 30 healthy physical examinees were enrolled for Negative control group. Patients in positive control group received routine treatment, while patients in treated group were given Edaravone 30mg twice a day intravenously for 14 days in addition. Serum levels of TNF-a and IL-6 were detected after cerebral infarction happened 12h, 24h, 48h, 72h, 7d, 14d, 30d later respectively, Then the score neurological impairment （SNI） was evaluated after treating one month later. Results Serum levels of TNF-a and IL-6 detected after acute cerebral infarction happened 72h later were higher than other periods and the time needed to recover to normal level were significantly different （treated group vs positive control group=14d vs 30d）. Serum levels of TNF-α and IL-6 declined sharply comparing treated group with positive control group when cerebral infarction happened 14d later （P〈0.05）. Conclusions Duing to the mechanism of reducing free radical, inhabiting inflammation, Edaravone would promote the recovery of neural function.