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应用MTPA确定手性仲醇绝对构型的研究进展 被引量:2

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摘要 实物与其镜像不能重合的现象称为手性。手性是自然界的本质属性之一,多数药物都具有手性。由于手性特征,手性药物分子与体内的药物靶点作用产生药理学效应时必然具有对应选择性,即往往产生不同甚至相反的药理学性,如沙利度胺(thalidomide)和布洛芬(ibuprofen)等。因此,包括手性药物分子在内的手性分子绝对构型的确定必然成为一个极其重要的课题。
作者 何玉玲 杜曦
出处 《泸州医学院学报》 2013年第3期293-296,共4页 Journal of Luzhou Medical College
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