溃疡性结肠炎肺损伤的病因病理机制探讨及意义

Discussion on etiology and pathogenesis of lung injury in ulcerative colitis and its significance

溃疡性结肠炎(UC)是一种病因不明的慢性非特异性肠道炎症,治愈难度大,常反复发作,甚至伴有肠外病变,被世界卫生组织列为现代难治病之一。然而UC肺损伤在我国尚未得到普遍认识。在中医毒邪学说、络病学说及肺与大肠相表里理论的指导下,创新性提出"毒损肠络"病机假说,并认为湿热瘀毒积久损伤肠络、毒邪上攻损肺是UC反复发作及出现肺部损害的病机关键,对提高UC疗效、降低复发、减少肠外并发症等具有重要意义。

Ulcerative colitis （UC） is a chronic disease characterized by diffuse mucosal inflammation limited to the colon, which is difficult to cure and easy to repeated attacks, even followed parenteral changes. It has been rated as one of contemporary refractory disease by WHO. Guided by the poison-evil theory, the collateral disease theory and the theory of the lung and the large intestine being interior-exteriorly related, we put forward ＇toxin impairing intestine collateral＇ pathogenesis theory and deem that damp-heat blood stasis toxin accumulating long damaging the intestine collateral and then upward attacking the lung is the key cause for the relapses of UC and the lung injury. This has important significance to improving curative effect of UC, reducing recurrence, decreasing the incidence of parenteral complications.