色氨酸羟化酶基因A218C多态性与愤怒启动及表达特质的关系

Asociation between hydroxylase gene A218C polymorphism and anger started as well as anger expression trait

目的:探讨色氨酸羟化酶(TPH)基因A218C多态性与愤怒启动及表达特质的关系。方法:用状态特质愤怒表达量表2(STAXI-2)筛选受试者,经采血、酚-氯仿法提取DNA、PCR-LDR法基因分型后,对数据进行统计分析。结果:①高、低特质怒两组中,基因型及等位基因频率分布差异无统计学意义。②高特质怒被试3个基因型组以下得分差异有统计学意义(P<0.05,P<0.01):发怒(AX-O),女性怒的表达(AX),男性郁怒(AX-I)。③低特质怒被试3个基因型组AX-I得分差异有统计学意义(P<0.05)。结论:TPH基因A218C多态性与中国正常大学生中高特质怒者的发怒特质、高特质怒女性怒的表达特质、高特质怒男性郁怒特质有关,还与低特质怒者的郁怒特质有关。

Objective： To discuss the association of tryptophan hydroxylase gene A218C polymorphism and anger started as well as anger expression trait.Methods： After the subjects were selected by STAXI-2 questionnaire,blood of them was sampled,DNA was extracted by phenol-chloroform method,genotyping by PCR-LDR method,and data was statistically analyzed.Results： ①There was no statistical significance of genotype and the allele frequency distribution of the subjects between the high and low trait anger groups.②For high trait anger subjects,there was statistical significance of the following scores of the subjects in three genotype groups（P〈0.05）： anger expression-out（AX-O）,anger expression（AX） of female,anger expression-in（AX-I） of male.③For low trait anger subjects,there was statistical significance of the scores of anger expression-in of the subjects in three genotype groups（P〈0.05）.Conclusion： There was the association of TPH gene A218C polymorphism with the following anger traits of normal college students with high trait anger in China： anger expression-out trait,anger expression trait of female,anger expression-in trait of male.The locus polymorphism was also related to the anger expression-in trait of normal college students with low trait anger in China.