下呼吸道感染的病原菌调查和耐药菌分析

Investigation on Pathogenic Bacteria of Lower Respiratory Tract Infection(LRTI) and Analysis on Drug-Resistance Bacteria

目的:了解我院临床下呼吸道感染分离病原菌对常用抗菌药物的耐药性,为临床合理用药提供参考。方法:临床分离病原菌采用纸片扩散法(K-B)进行药敏试验,并按CLSI标准判断结果。结果:2009、2010、2011年下呼吸道感染病原菌仍以革兰阴性菌为主,分别占71.5%、70.9%、86.2%。虽然分离出的主要病原菌对常用抗菌药物耐药率较高,但超广谱β-内酰胺酶(ESBLs)检出率有逐年下降趋势。结论:采取有效措施,加强病原菌的耐药监控,合理使用抗菌药物。

Objective：To understand the drug resistance of isolated pathogenic bacteria to common antibacterial and thus provide a reference for clinical LRTI treatment.Method：Adopt K-B disk diffusion method to conduct drug sensitive test on the clinical isolated pathogenic bacteria and then determine the result according to CLSI Standard.Result：The pathogenic bacteria of LRTI in the year of 2009,2010,2011 is still dominated by Gram-negative bacteria and respectively account for 71.5%,70.9%,86.2%.Although the isolated dominant pathogenic bacteria have a high antibiotics resistance rate,the detection rate of Extended-Spectrumβ-lactamase（ESBLs） presents a decrease trend year by year.Conclusion： Take effective measures to strengthen the drug-resistance monitoring on pathogenic bacteria so as to use antibacterial correctly.