吡唑醚菌酯的主要中间体N-甲氧基-N-2-甲基苯基氨基甲酸甲酯的合成工艺改进

Synthesis Improvement of Methyl N-methoxyl-N-2-methylphenylcarbamate

介绍了以邻硝基甲苯为起始原料,经锌粉还原法制备吡唑醚菌酯的主要中间体N-甲氧基-N-2-甲基苯基氨基甲酸甲酯的工艺改进。重点解决了邻甲基苯基羟胺不稳定问题,3步总收率达到69%,纯度超过98%。

A synthesis method of the key intermediate of pyraclostrobin, methyl N-methoxyl-N-2-methylphenylcarbamate by using o-nitrotoluene as raw materials and zinc powder as the reducing agent was improved. The total yield was more than 69% based on o-nitrotoluene, and the purity was higher than 98%.