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细胞因子及肠脂肪酸结合蛋白在新生儿坏死性小肠结肠炎早期诊断中的价值探讨 被引量：11

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摘要 目的探寻细胞因子及肠脂肪酸结合蛋白(I-FABP)早期诊断新生儿坏死性小肠结肠炎(NEC)的价值。方法对30例NEC患儿(NEC组)和45例非NEC患儿(非NEC组)病程中TNF-α、IL-6、IL-8、肠脂肪酸结合蛋白(I-FABP)水平(ELISA法测定)进行分析,并35例正常早产儿(对照组)比较。结果第1次检查(出现NEC可疑症状时):各组血清TNF-α、IL-6、IL-8水平无统计学差异;但NEC组血清I-FABP水平明显高于非NEC组和对照组(P均<0.05)。第2次检查(第1次抽血后2～3 d):NEC组及非NEC组(20例)患儿血清TNF-α、IL-6、IL-8水平无统计学差异,而NEC组I-FABP水平仍高于对照组与非NEC组(P均<0.05)。结论 I-FABP可作为早期诊断NEC较理想的生物学指标。
作者 李粹 任雪云 蔡文仙 牛峰海
机构地区 济宁医学院附属医院
出处 《山东医药》 CAS 2013年第14期50-51,共2页 Shandong Medical Journal
关键词 新生儿坏死性小肠结肠炎 血清 肿瘤坏死因子Α 白细胞介素6 白细胞介素8 肠脂肪酸结合蛋白
分类号 R725.7 [医药卫生—儿科]
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参考文献12

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共引文献15

同被引文献77

  • 1崔龙.提高外科手术在溃疡性结肠炎治疗中的作用[J].中华结直肠疾病电子杂志,2014,3(3):2-4. 被引量：6
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引证文献11

二级引证文献46

山东医药
2013年 第14期

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