摘要
偏头痛是一种常见的慢性发作性疾病,普通人群中约有6%的男性和18%的女性罹患此病。根据2004年国际头痛协会(HIS)分类标准,偏头痛分为有先兆偏头痛(MA)和无先兆偏头痛(MO)。家族性偏瘫型偏头痛(FHM)是少见的常染色体显性遗传、具有先兆症状的偏头痛,是目前惟一明确的单基因遗传偏头痛。本文就FHM的遗传学研究进展及有待解决的问题进行综述,为临床提供参考。
Migraine is a common recurrent neurological disease, and about 6% of men and 18% of women in the generalpopulation are affected. In 2004,the International Headache Society （ HIS ） divided the migraine into two classes ： migraine with aura（MA） and migraine without aura （MO）. Migraine is a disease with an obviously familial concentration. Its etiology is still un-clear. Familial hemiplegic migraine （ FHM） , being autosomal dominant inheritance, is the only one known as single gene inherit-ance. This paper reviews a variety of factors and candidate genes associated with FHM, and focuses on the known genes of CAC-NL1A4 and ATP1A2 in order to provide references for clinical physicians.
出处
《中国全科医学》
CAS
CSCD
北大核心
2013年第18期2074-2075,共2页
Chinese General Practice
关键词
偏头痛
先兆偏头痛
遗传
综述
Migraine disorders；Migraine with aura；Hereditary；Review
