普米克令舒雾化吸入联合静脉丙种球蛋白治疗婴儿毛细支气管炎的疗效观察

Observation of Therapeutic Effect of Pulmicort Respules Atomizing Inhalation Combined with Intravenous Gamma Globulin in Treatment of Infant Bronchiolitis

目的:观察探讨普米克令舒、万托林雾化吸入联合静脉丙种球蛋白应用于婴儿毛细支气管炎治疗的效果。方法:将笔者所在科室2012年1月-11月收治的138例毛细支气管炎患儿作为研究对象,并随机分为治疗组(74例)和对照组(64例)。两组患者将所有患儿咳嗽、憋喘、肺部湿啰音及哮鸣音消失时间作为临床疗效观察指标,两组间进行对比,且对所得数据进行统计学处理。结果:治疗组74例患儿中,治疗效果显著者38例,有效30例,无效6例,治疗有效率为91.90%;对照组64例患者中,治疗效果显著者30例,有效20例,治疗无效者14例,治疗有效率为78.13%。两组间相较,治疗组治疗效果显著高于对照两组,差异有统计学意义(P<0.05)。另外,两组在咳嗽、憋喘症状消失时间,肺部湿啰音、哮鸣音消失时间及住院时间方面差异有统计学意义(P<0.05)。结论:普米克令舒雾化吸入联合静脉丙种球蛋白对婴儿毛细支气管炎疗效确切,值得临床实践进一步推广。

Objective： To explore the Pulmicort Respules inhalation of ventolin, combined with intravenous gamma globulin in treatment of infant bronehiolitis effect. Method： In our department from 2012 January to 2012 November, 138 cases of bronchiolitis were treated as the research object, and were randomly divided into treatment group （ 74 cases ） and control group （ 64 cases ） . Two groups of patients all children cough, wheeze, pulmonary rales and wheezes disappeared time as clinical observation indexes, compared between the two groups, and the data statistics processing. Result： The treatment group of 74 cases, 38 cases with obvious curative effect, 30 cases effective, 4 cases ineffective, the effective rate was 91.90%; the control group of 64 patients, 30 cases with obvious curative effect, 20 cases effective, ineffective treatment in 14 cases, the effective rate of treatment was 78.13%. Between the two groups in the therapeutic effect, treatment group was significantly higher than that of control group, there were significant differences （ P〈0.05 ） . In addition, two groups of cough, wheeze symptoms disappeared time, pulmonary rales, wheeze disappeared time and hospitalization time were significant difference （P〈O.05） . Conclusion： 1%lmicort Respules atomizing inhalation combined with intravenous gamma globulin has definite effect on infant bronehiolitis, worthy of clinical practice and further promotion.