维生素D的临床研究进展

Clinical research progress of vitamin D

近年来的研究发现维生素D不仅在骨骼疾病中发挥重要作用,在非骨骼疾病中也起到十分重要的作用。基础研究证实维生素D受体广泛分布于体内各种组织细胞中,越来越多的临床研究发现补充维生素D在预防和治疗骨质疏松症、心脑血管病、肺部疾病、慢性代谢性及肿瘤性疾病中有重要作用。本文就维生素D与上述疾病关系的研究进展进行综述,主要着眼于当前的临床热点研究方面。结果显示观察性研究证据支持维生素D与上述非骨骼系统疾病有很强的相关性,但是尚缺乏大规模和长期的随机临床试验证据,因此,需要更多的研究来探讨补充维生素D在预防和治疗非骨骼疾病中的作用。

Researches in recent years have found that vitamin D plays an important role not only in skeletal diseases, but also in non-skeletal diseases. Basic researches have confirmed that vitamin D receptors are widely distributed in all kinds of cells in vivo. More and more clinical studies have found that vitamin D plays an important role in the prevention and treatment of osteoporosis, cardiovascular and cerebrovascular diseases, lung diseases, and chronic metabolic and neoplastic diseases. In this paper, we review the research progress of the relationship among vitamin D and the diseases mentioned above, and mainly focus on the clinical aspects of current hot research. The results show that the observational studies support strongly correlation among vitamin D and the non-skeletal diseases mentioned above. But there still remains a paucity of large-scale and long-term randomized clinical trials. Therefore, more clinical studies are needed to clarify the effect of vitamin D supplementation on preventing and treating non-skeletal diseases.