血清同型半胱氨酸、胱抑素C、白细胞介素-6水平与老年冠心病合并抑郁情绪的关系

The relationship between depression and serum homocysteine,cystatin C and interleukin-6 levels in elderly patients with coronary heart disease

目的探讨血清同型半胱氨酸、胱抑素C、白细胞介素-6水平与老年冠心病合并抑郁情绪的关系。方法收集老年冠心病患者103例,进行ZUNG抑郁自评量表(SDS)评分,根据评分结果分为冠心病伴有抑郁组与不伴抑郁组,记录年龄、性别、体质量指数等一般资料,并测定血清同型半胱氨酸、胱抑素C、白细胞介素-6,血脂水平等相关资料。结果 103例冠心病患者中男性46例(44.66%),女性57例(55.34%),伴有抑郁情绪59例(57.28%),其中男性有21例(35.6%),女性38例(64.5%),男女冠心病患者伴抑郁情绪差异有统计学意义,冠心病伴有抑郁组同型半胱氨酸、胱抑素C、白细胞介素-6明显高于对照组,差异均有统计学意义。结论同型半胱氨酸、胱抑素C、白细胞介素-6水平升高对老年冠心病抑郁情绪的发生、进展具有重要意义。

Objective To study the relationship between depression and serum homocysteine,cystatin C and interleukin-6 levels in elderly patients with coronary heart disease. Methods 103 cases of elderly patients with coronary heart disease with or without depression were divided into two groups, the elderly patients with coronary heart disease and depression（ group A） and the elderly patients with coronary heart disease and no depression（ group B）. Their age, gender, body mass index and other general information were recorded and the levels of serum homocysteine, cysta- tin C,interleukin-6,1ipids and other related subjects were tested. Results Among the 103 cases of patients 46 cases of men（44.66% ） ,57 cases of women（55.34% ） ,there were 59 cases（57.28% ） of patients accompanied by depression,in which the males were 21 cases（35.6% ） and the females were 38 cases（64.5% ） ,there was statistically significant difference between the males and females in depressive mood. Coronary heart disease patients accompanied with depression had a higher level of serum cysteine, cystatin C and interleukin-6, than those in control group significant. Conclusion Serum homocysteine,cystatin C and interleukin-6 levels are related with the occurrence, development, treatment and prognosis of elderly coronary heart disease patients with depression.