睑板腺功能障碍的临床疗效分析

Analysis of the efficacy in the treatment of meibomian gland dysfunction

目的:分析妥布霉素地塞米松眼膏治疗睑板腺功能障碍(meibomain gland dysfunction,MGD)的短期临床效果。方法:选择2012-01/06诊治的MGD患者87例174眼,所有患者按照就诊顺序分为红霉素眼膏组、妥布霉素地塞米松眼膏组和对照组,分析治疗前、治疗后1wk和4wk的观察指标。结果:三组患者的症状评估(SS)、泪膜破裂时间(BUT)、角膜荧光素染色评分(CFS)、基础泪液分泌量(SⅠt)、睑缘观察评分(LMS),治疗前与治疗后1wk和4wk比较,存在统计学差异(P<0.05),说明三种治疗皆有效;治疗后1wk和4wk,红霉素眼膏和妥布霉素地塞米松眼膏组与对照组比较,在SS和LMS方面存在统计学差异(P<0.05);治疗后1wk和4wk妥布霉素地塞米松眼膏组和红霉素眼膏在SS,BUT和LMS方面存在统计学差异(P<0.05),说明妥布霉素地塞米松眼膏组以上指标效果优于红霉素眼膏组。结论:妥布霉素地塞米松眼膏对MGD临床效果良好,不但能够改善MGD患者的症状体征,而且抗炎效果满意。

AIM： To analyze the clinical effects of topical tobramycin- dexamethasone coulentum in the treatment of meibomian gland dysfunction （MGD）. METHODS： Totally 87 MGD patients （174 ）eyes were chosen from January 2012 to June 2012. All patients were divided into three groups according to medical order. Observation index was analyzed before treatment, 1 week after treatment, 4 weeks after treatment. RESULTS： There were statistical difference in symptoms scores （SS）, breakup time of tear film （BUT, corneal fluorescein staining scores （CFS）, Schirmer I test （S I t）, limbi margin scores （ LMS） before treatment and 1 week, 4 week after treatment among three groups by paired tests. SS and LMS at 1 week, 4 weeks after treatment in observation group were better than that in control group, there were statistical differences, and there were statistical differences in above indicators between Erythromycin eye ointment group and observation group, observation group were superior to Erythromycin eye ointment group. CONCLUSION： Topical tobramycin - dexamethasone coulentum is effective for MGD. It can significantly improve the symptoms and signs for patients with MGD. Its effect is satisfied.