210例乳腺癌患者的危险因素分析

Analysis of risk factors on 210 patients of breast cancer

目的:通过对乳腺癌患者临床资料的调查分析,了解乳腺癌的临床流行病学特征,探讨乳腺癌发病的相关危险因素,为乳腺癌的预防提供一定的参考依据。方法:采用病例对照研究方法,选取2005年1月—2012年1月经病理学确诊的乳腺癌患者210例作为病例组,同时随机选择同期已证实为良性乳腺疾病的210例患者作为对照组,采用统一设计的调查表,由经过统一培训的调查员对研究对象进行面对面的问卷调查。单因素分析采用单因素条件Logistic回归分析,多因素分析采用条件Logistic回归模型进行统计分析,探讨与乳腺癌的发病有关的危险因素。结果:单因素分析结果显示,文化程度高、接触职业性有害物质、被动吸烟、绝经年龄大、流产、肿瘤家族史、长期精神压抑、负性生活事件、肉类烟熏食物摄入次数多这9个因素是乳腺癌的危险因素;体育运动、初潮年龄晚、月经规律、生育孩子次数多、母乳喂养、母乳喂养持续时间长以及蔬菜摄入次数多这7个因素是乳腺癌的保护因素。多因素分析结果显示,文化程度高、绝经年龄大、肿瘤家族史、负性生活事件、肉类摄入次数多是乳腺癌的危险因素;初潮年龄晚、月经规律、母乳喂养持续时间长、蔬菜摄入次数多为保护因素。结论:乳腺癌患者住院治疗人数呈显著增加趋势,其发生与患者的居住环境、生活方式和习惯、女性生理与生育、家族史、饮食因素、精神心理因素密切相关,因此对其的预防应采取具有针对性的综合性措施。

Objective： The aim is to analysis the breast cancer patients of Traditional Chinese Medicine Hospital of Wansheng economic and Technological Development District,to explore the related risk factors that affect the occurrence of breast cancer,provide reference for the prevention of breast cancer.Methods： A case-control study method to select January 2005-2012 January 210 cases of pathologically-confirmed breast cancer patients in our hospita（lTraditional Chinese Medicine Hospital of Wansheng,Wansheng economic and Technological Development District,Chongqing）as the case group,randomly selected over the same period has been confirmed210 cases of benign breast disease patients as a control group,using a unified design questionnaire,face-to-face survey study by investigators after uniform training.Univariate analysis a single conditional logistic regression analysis,multivariate analysis using conditional logistic regression model for statistical analysis,to explore the risk factors related to the incidence of breast cancer.Results： Univariate analysis results show a high degree of cultural contact with harmful substances,occupational passive smoking,menopausal age,abortion,family history of cancer,chronic mental depression,negative life events,meat,smoked food intake more times this 9 factor is a risk factor for breast cancer;sports,late age at menarche,menstrual regularity,have children more often,breastfeeding,breastfeeding duration and vegetable intake,more often these seven factors are protective factors for breast cancer.Multivariate analysis results show that the high level of education,age at menopause,family history of cancer,negative life events,the number of meat intake is more than breast cancer risk factors;late age at menarche,menstrual regularity,breastfeeding duration,vegetables intake more than the number of protective factors.Conclusion： The number of hospital treatment of breast cancer patients was significantly increasing trend occurred with patients living environment,lifestyle and habits,menstrual and fertility,family history,dietary factors,psychological factors are closely related to its prevention should be taken with a targetedsexual comprehensive measures.