中国大陆地区在SCI期刊上发表的眼科随机对照试验论文统计

Statistical analysis of ophthalmic diseases related randomized controlled trials published in SCI journals from China's Mainland

背景近年来中国发表在国际期刊上的眼科随机对照试验（RCT）论文逐渐增多，目前尚缺乏系统的整理和归纳。目的系统检索并统计分析中国大陆地区截止2012年11月1日在SCI期刊上发表的有关眼科疾病的RCT论文。方法在Pubmed检索平台，以Ophthalmology、Eye及其所有下位主题词、文献类型限定为randomized controlled trial、国家限定为China进行检索。对于检索到的文献进行筛选、数据提取和分析。结果中国大陆地区自1989年以来共发表68篇眼科疾病方面的RCT论文，其中2005年后数量迅速增长，2006年7篇，2009年11篇，2011年15篇。68篇RCT论文集中在白内障、眼视光、青光眼、角膜结膜病、眼免疫／药理和眼底病等领域，共发表在35种SCI期刊上，覆盖了大多数的SCI眼科期刊，如Ophthalmology和IOVS等，以及少量其他专业期刊，其中发表论文最多的期刊为Clin Experiment Ophthalmol（8篇）。68篇RCT论文来自中国26家单位，主要为广州、北京、上海、温州和杭州等地的医学院校附属医院。结论中国大陆地区在SCI期刊上所发表的眼科疾病相关的RCT论文数量持续增多，主要集中在白内障、眼视光和青光眼等领域，RCT论文的总体数量仍较少，且存在地区间分布不均衡。

Background Recently,the number of randomized controlled trials on ophthalmic diseases that published in international journals from China's Mainland has increased gradually. There is no systematic summary in this field. Objective To systematically search and analyze the distribution of ophthalmic diseases related randomized controlled trials （RCT） published in SCI journals from China's Mainland up to November, 2012. Methods The search was performed on Pubmed using ＂Ophthalmology＂ ,＂Eye＂ and all of their inferior subjective terms,with type of literature being limited as randomized controlled trial, and country as China. All retrieved papers were screened, data extracted and analyzed. Results There were 68 ophthalmic diseases related RCT papers published from China's Mainland since 1989. After 2005, the number of RCT papers from China's Mainland increased quickly with 7 in 2006,11 in 2009, and 15 in 2011. The 68 RCT papers were focused on cataract, optometry, glaucoma,corneal and conjunctival diseases, ophthalmic immune and pharmacology, and fundus diseases. The RCT papers were published in a total of 35 SCI journals including most kinds of ophthalmic journals such as Ophthalmology, IOVS and a few journals on other specialty. The journal Clin Experiment Ophthalmol had the maximum RCT papers from China （8 papers）. The 68 RCT papers came from 26 departments in China's Mainland,mainly from the hospitals affiliated to medical university in Guangzhou, Beijing, Shanghai, Wenzhou and Hangzhou. Conclusions The number of ophthalmic diseases related RCT papers published in SCI journals from China's Mainland increased continuously. The papers were mainly focused on cataract, optometry and glaucoma. The number of these papers, however,was still small and imbalance between districts existed.