新型C型凝集素受体mincle的研究进展

Advances in the study of mincle, a new C-type lectin receptor

巨噬细胞诱导型C型凝集素受体mincle是一种新发现的非经典型C型凝集素受体，主要表达于抗原递呈细胞表面，可以在某些真菌、结核分枝杆菌、坏死细胞的刺激下与相关配体结合，激活核因子-κB（NF—κB）途径，引起炎性因子的表达，从而在宿主的固有免疫应答过程中发挥一定的作用。目前，mincle受体在一些免疫相关疾病中作用机制的研究成为热点，但关于其在眼科炎性感染性疾病中作用的研究甚少，深入研究mincle受体与眼科感染性疾病的关系可以为相关疾病的免疫治疗提供新的思路。就mincle受体的基本概念、作用机制、与炎性疾病的关系以及其在眼科疾病研究中的展望进行综述。

Macrophage-inducible C-type lectin （mincle receptor） is a novel unclassical C-type lectin receptor member, which is mainly expressed on the surface of antigen presenting cells. Under the stimulation of fungus,mycobacterium tuberculosis and necrotic cells, mincle receptor plays anatural immune effect in host body by binding to relevant ligand and activate nuclear factor-κB （NF-κB） signaling pathway ,which promotes the expression of many inflammatory factors. Up to now, the laboratory and clinical studies on mincle receptor and infected diseases is being a hot topic. However,these study is lack in ophthalmology. Understanding the association of mincle receptor to infected eye diseases will offer a new approach to the immunotherapy. The basic concept,acting mechanism,its relationship to inflammatory eye diseases and outlook in ophthalmology of mincle receptor were reviewed in this paper.