摘要
目的：研究母源性甲亢对胎鼠、仔鼠心的影响。方法：建立妊娠合并甲亢模型；取孕16、18、20d胎鼠心，出生5、10、15d仔鼠心，解剖检查；经石蜡包埋，Masson染色，测量心肌细胞直径和长度；免疫组织化学检测内皮素的差异表达。结果：母源性甲亢各组胎鼠、仔鼠心质量分数高于同期对照组，心肌细胞直径加大、细胞加长，心肌排列不整齐且胶原纤维增多，内皮素的表达高于同期对照组。结论：母源性甲亢会影响胎鼠、仔鼠心肌细胞。
Objective： To study the influence of hyperthyroidism on the foetus and neonatus of rats. Methods： A model of hyperthyroidism with pregnancy was established. The hearts of 16% day, 18% day and 20^th day after gestation and 5^th day, 10^th day and 15^th day after parturition were obtained. The cardiac tissues were measured and observed by paraffin imbedding and Masson staining. The expression of endothelin was detected through immunohistochemistry. Results： The myocardial cells of maternal hyperthyroidism were bigger than the normal ones. The eollagenous fibers in cardiac muscle increased in the group of maternal hyperthyroidism. And the expression of endothelin was hgiher than the normal ones. Conclusion： The maternal hyperthyroidism can influence the myocardial cells of the foetus and neonatus.
出处
《解剖学杂志》
CAS
CSCD
北大核心
2013年第3期317-320,共4页
Chinese Journal of Anatomy
基金
内蒙古自然科学基金（2010MS1130）
关键词
母源性甲亢
心
胎鼠
仔鼠
内皮素
maternal hyperthyroidism
heart
foetus
neonatus
endothelin
