脂质及其在合体滋养细胞微粒导致子痫前期过程中的影响

Lipid Level and Its Impact on Syncytiotrophoblast Microparticles Inducing Preeclampsia

微粒是细胞受到刺激活化或凋亡后产生的细胞碎片,在循环中微粒作为运载工具承载和转运多种蛋白质、DNA片段和RNA片段,在细胞间信号传递过程起作用。微粒可以促进血栓形成,介导促炎效应,也可能直接导致内皮细胞功能紊乱。体内多种细胞都可以产生微粒。研究发现子痫前期患者体内合体滋养细胞微粒的释放明显多于正常妊娠者。体外研究还发现,微粒样品中脂质水平对脐静脉内皮细胞的增殖及凋亡也有影响。脂质水平越高,则微粒样品抑制脐静脉内皮细胞增殖和促进其凋亡的能力就越强。摄入高脂饮食者循环中微粒总量较正常饮食者高。

Microparticles are cell fragments that derived from cell activation and/or apoptosis.Cycling microparticles can serve as vehicles carrying and transporting varieties of proteins and frangements of DNA or RNA.Microparticles can promote thrombus formation,mediate pro-inflammatory effects and may cause endothelial dysfunction directly.Most kinds of cells in human can produce microparticles.Studies have found a much higher formation of syncytiotrophoblast microparticles in preeclampsia women than normal pregnancies.Studies in vitro also found that the lipid levels in microparticles can impact their abilities of inhibiting proliferation and promoting apotosis in human umbilical vein endothelial cell.The higher lipid levels,the stronger abilities to inhibit proliferation and promote apoptosis.In another study,volunteers intaking high fat diet have higher level of total circulation microparticles than normal diet.