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可溶性血管内皮生长因子受体-1与胎盘生长因子在子痫前期诊断中的应用 被引量：10

The Significance of Clinical Studies of sFlt-1 and PLGF in Preeclampsia
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摘要 归纳子痫前期的病理生理过程以及可溶性血管内皮生长因子受体-l(sFlt-1)、胎盘生长因子(PLGF)与子痫前期的研究情况,PLGF是血管内皮生长因子(VEGF)家族成员之一,PLGF与Flt-1受体结合时,发挥促血管生成和促绒毛滋养细胞增殖、浸润的效应,而这些生物学功能均可被sFlt-1阻断,且sFlt-1对PLGF具有强效的拮抗作用,调节PLGF的功能。在子痫前期妊娠妇女血清中sFlt-1的水平升高,早于疾病的发生。子痫前期患者血浆中PLGF的水平降低。总结sFlt-1、PLGF预测诊断子痫前期发生及病情严重程度的研究进展,探讨sFlt-1、PLGF在子痫前期临床诊断中的意义。 This summary aims to generalize the pathological process of the preeclampsia and its relationship with sFlt-1 and placental growth factor（PLGF）.PLGF is a member of the VEGF family,PLGF binds with Flt-1 receptor,and promotes angiogenesis and trophoblast proliferation.These biological functions can be blocked by sFlt-1 receptor,sFlt-1 plays an important role in regulation PLGF.sFlt-1 concentrations are higher in preeclampsia serum and prior to the onset of the disease.Levels of PLGF are lower in preeclampsia serum compare to normal.This summarizes up the roles sFlt-1 and PLGF have played in the prediction of the diagnosis of preeclampsia as well as its seriousness,exploring the significance of the application of sFlt-1 and PLGF in the clinical diagnosis of preeclampsia.
作者 杨智宇 陈立芬
机构地区 安徽省马鞍山市妇幼保健院
出处 《国际妇产科学杂志》 CAS 2013年第3期222-225,共4页 Journal of International Obstetrics and Gynecology
关键词 先兆子痫 血管内皮生长因子受体-l 胎盘生长因子 Pre-eclampsia Vascular endothelial growth factor receptor-1 Placental growth factor
分类号 R714.2 [医药卫生—妇产科学]
  • 相关文献

参考文献25

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二级参考文献20

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共引文献7

同被引文献112

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引证文献10

二级引证文献96

国际妇产科学杂志
2013年 第3期

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