白介素12基因多态性与恶性肿瘤易感性的Meta分析

Interleukin-12 gene polymorphisms and cancer risk: a meta-analysis

目的 Meta分析方法评价白介素12(IL-12)基因多态性与恶性肿瘤易感性的具体关联。方法全面检索相关中英文数据库,收集有关IL-12基因多态性与恶性肿瘤易感性关联的病例对照研究,由两位研究者分别独立提取数据,汇总数据采用STATA 12.0软件进行分析,采用优势比(odds ratio,OR)及其95%可信区间(95% confidence interval,95%CI)描述关联。结果严格根据纳入和排除标准,最终纳入18项病例对照试验,包括6463例恶性肿瘤患者和7412例健康对照。Meta分析结果表明:IL-12B基因的3'UTRA>C多态可能会增加恶性肿瘤发生风险(C vs A:OR=1.13,95%CI:1.01～1.26,P=0.038;AC+CC vs AA:OR=1.20,95%CI:1.01～1.43,P=0.038);然而,IL-12A基因的3'UTRG>A、IVS2T>A和5'UTRT>G多态与恶性肿瘤易感性无明确统计学关联。亚组分析表明,IL-12B基因的3'UTRA>C多态与亚组人群恶性肿瘤易感性增加密切相关,尤其是宫颈癌和鼻咽癌。结论现有证据表明,IL-12B基因的3'UTRA>C多态可能是亚洲人群恶性肿瘤易感性增加的危险因素,尤其是宫颈癌和鼻咽癌。

Objective The aim of this study was to investigate the association between the interleukin-12 （IL-12） gene polymor-phisms and cancer risk. Methods Electronic databases were searched for all articles published that addressed IL-12 gene polymor-phisms and cancer risk. Statistical analyses were performed using STATA 12.0 software. Results were described as odds rate （OR） with 95% confidence intervals （CI）. Results Eighteen studies were included with a total of 6463 cancer cases and 7412 healthy controls. We found that the 3＇UTR A 〉 C polymorphism of IL-12B gene was associated with significantly increased overall risk of cancers using random effects model （C vs A ： OR = 1.13, 95% CI ： 1.01 ～ 1.26, P = 0. 038 ; AC ＋ CC vs AA ： OR = 1.20, 95% CI： 1. 01 ～ 1.43, P =0. 038）. However, the 3＇UTR G 〉 A, IVS2 T 〉 A and 5＇UTR T 〉 G polymorphisms of IL-12A gene did not appear to have an influence on cancer susceptibility. Further subgroup analyses showed that the 3＇UTR A 〉 C polymorphism was as- sociated with increased cancer risks in the subgroups of Asians, cervical and nasopharyngeal cancers. Conclusion Results from the current meta-analysis indicates that the 3＇UTR A 〉 C polymorphism of IL-12B gene might be a potential biomarker for cancer risk a- mong Asians, especially for cervical and nasopharyngeal cancers.