早发和晚发冠心病患者冠脉病变特点及经桡动脉介入治疗近期效果观察

Coronary angiographic characteristics of patients with premature and late-onset coronary heart disease and short-term outcome after transradial coronary intervention

目的探讨早发冠心病(PCAD)与晚发冠心病(LCAD)患者的冠脉病变特点及观察经桡动脉介入治疗效果,并对两组患者住院期间主要不良心脏事件(MACE),主要包括死亡、心肌梗死、再次靶病变血运重建发生情况进行对比分析。方法总结分析经桡动脉介入治疗的PCAD(58例)和LCAD(80例)的病例资料,比较两组病例的冠脉病变特点、支架置入数和长度以及介入治疗并发症、住院期间MACE发生率。结果 PCAD组患者冠脉病变多累及左回旋支(LCX)、右冠状动脉(RCA);PCAD组介入治疗所需支架总数、长度少于LCAD组,差异具有统计学意义(P<0.01);血管径路并发症、冠脉夹层、冠脉穿孔比例、介入成功率方面两组比较无统计学差异;MACE发生率PCAD组低于LCAD组,差异具有统计学意义(P<0.05);PCAD组患者介入治疗并发症少于LCAD患者。结论 PCAD患者冠脉病变多在LCX、RCA,介入治疗MACE发生率低。

Objective To analyse the coronary angiographic characteristics of premature coronary heart disease（PCAD） and Late-onset coronary heart disease（LCAD）.In-hospital Short-term outcome after transradial coronary intervention and major adverse cardiac events（MACE） including death,myocardial infarction,and lesion revascularization for patients with PCAD and LCAD are also explored in the study.Methods Clinical data of 58 patients with PCAD and 80 patients were summarized and analyzed.The coronary angiographic characteristics,number and length of implanted stent,complications of interventional treatment,and MACE during hospitalization between the two sets were compared.Results Left Circumflex Artery（LCX） and Right Coronary Artery（RCA） are the most frequently involved vessels in patients with PCAD.Compared with LCAD group,patients in PCAD group requires less and shorter stents implanted,which has a significance（P 0.05）.There were no differences in vascular complications,coronary dissection,coronary artery perforation,and successful rate of interventional treatment between two groups.The incidence rate of MACE and the complications of interventional therapy in PCAD group are less than that in LCAD group（P 0.05）.Conclusion For patients with PCAD,LCX and RCA are the vessels which are involved the most frequently,and interventional therapy reduces the incidence rate of MACE.