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盐酸苯达莫司汀的合成优化 被引量:2

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摘要 盐酸苯达莫司汀(BendamustineHydrochloride,如图化合物III)是一种双功能基烷化剂,具有抗肿瘤和杀细胞作用。19世纪60年代初期由Ozegowski和其同事在德国耶拿的微生物试验协会研制。
作者 梁西周
出处 《中国化工贸易》 2013年第6期288-288,共1页 CHINA CHEMICAL TRADE
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  • 1Teichert J, SohrF, Baumann F, et al. Synthesis and charac- terization'of some new phase metabolites of the alkylator- bendamustine and their identification in human bile and plasma from patients with cholangiocarcinoma [ J ]. Drug Metab Dispos ,2005,33 (7) :984-992.
  • 2Jian C, Katrin P. Discover of a nove] efficient and scalable route to bendmustine hydrochloride: The API in treanda [ J]. Org Process ires Dev,2011,15(5) :1 063-1 072.
  • 3方新德.葫芦素类化学成分的化学与生物活性的研究进展[J].国外医学药学分册.1985,12(3):132-135.
  • 4Jayapra Kasam B, Seeram NP, Nair MG. Anticancer and anti-inflammatory activities of cucurbitacins from Cucurbi- ta and reana[ J]. Cancer Lett,2003,189( 1 ) :11-16.
  • 5高丽梅,汪燕翔,宋丹青.盐酸苯达莫司汀的合成[J].中国新药杂志,2007,16(23):1960-1961. 被引量:14
  • 6王先登,刘立力,张广明.一种高纯度的盐酸苯达莫司汀的合成方法:CN101691359A[P],2009.
  • 7Jian C, Katrin P. Discover of a novel efficient and scalable route to bendmustine hydrochloride:The API in treanda[ J 1. Org Process Res Dev, 2011,15 (5) : 1063 - 1072.
  • 8陈栋,宫平.盐酸苯达莫司汀[J].中国药物化学杂志,2009,19(2):159-160. 被引量:11
  • 9王晓坤.新型抗肿瘤药物——苯达莫司汀[J].齐鲁药事,2009,28(9):573-574. 被引量:4
  • 10戴延凤,张胜菊,付敏,孔亚芬,刘传飞.盐酸苯达莫司汀的合成[J].化学试剂,2010,32(8):753-755. 被引量:8

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