莫西沙星序贯治疗社区获得性肺炎的Meta分析

Meta-analysis of Moxifloxacin Sequential Therapy of Community-acquired Pneumonia

目的:系统评价莫西沙星序贯治疗社区获得性肺炎的临床有效性和安全性。方法:采用计算机和手工检索相结合的方法,检索2005年1月～2012年11月国内公开发表的莫西沙星序贯治疗社区获得性肺炎的相关文献,采用RevMan 5.0对符合条件的文献进行Meta分析。结果:共有9篇文献,815例患者满足纳入标准。Meta-分析结果显示,莫西沙星序贯治疗社区获得性肺炎与对照组比较,临床有效率方面的OR为0.74,95%CI为(0.46,1.16);细菌清除率方面的OR为0.80,95%CI为(0.41,1.56);不良反应发生率方面的OR为0.59,95%CI为(0.35,0.99)。结论:莫西沙星序贯治疗社区获得性肺炎的临床有效率与细菌清除率与对照组相似,但不良反应少于对照组,但本次研究仍有局限性,需大样本多中心随机对照临床试验进一步证实。

Objective：To evaluate the clinical efficacy and safety of moxifloxacin sequential therapy of community -acquired pneumonia.Methods：The computer and manual searches were combined to explore relevant references published from Jan.2005 to Nov.2012 in China on the effect of moxifloxacin sequential therapy of community-acquired pneumonia and the meta-analysis of the qualified references was made.Results：9 references and 815 patients met the inclusion criteria.Moxifloxacin sequential therapy of commuity acquicred penumcnia compared with controlled group,the systematic review showed that the total OR effective rate was 0.74,and 95%CI was（0.46,1.16）.The bacterial clearance OR rate was 0.80,and 95%CI was（0.41,1.56）.The OR incidence of adverse drug reaction was 0.59,and 95%CI was （0.35,0.99）.Conclusion：The effect of moxifloxacin sequential therapy of community-acquired pneumonia was similar to that of the controlled group,but the adverse reactions were fewer than those of the controlled group.However,due to limitations of the included studies,the clinical effects need to be confirmed by large multicentor randomized controlled trials.