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SNP基因分型检测技术及应用进展 被引量:11

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摘要 单核苷酸多态性(single nucleotide polymorphism,SNP)是人类最普遍的遗传变异形式之一,指在基因组水平上由单个核苷酸变异所引起的DNA序列多态性。SNP即指在种群中发生在给定的遗传区域内且频率最小为1%的核苷酸变异。SNP广泛存在于人类基因组中,平均每500到1000个碱基对中就有1个,目前发现其总数已达3700万。随着人类后基因组时代的开始,
出处 《中国药师》 CAS 2013年第6期811-816,共6页 China Pharmacist
基金 国家自然科学基金资助项目(编号:81273591) 湖北省自然科学基金资助项(编号:2009CDB380) 中央高校基本科研业务费专项资金资助(编号:2011JC039)
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参考文献27

  • 1Marian AJ. Molecular genetic studies of complex phenotypes [ J]. Transl Res, 2012, 159(2) :64-79.
  • 2Crawford A, Fassett RG, Geraghty DP, et al. Relationships between single nucleotide polymorphisms of antioxidant enzymes and disease [J]. C, ene, 2012, 501(2) :89-103.
  • 3Morlighem JE, Harbers M, Traeger-Synodinos J, et al. DNA amplifi- cation techniques in pharmacogenomics [ J ]. Pharmcogenomics, 2011,12(6) :845-860.
  • 4Thelwell N, Millington S, Solinas A, et al. Mode of action and appli- cation of Scorpion primers to mutation detection [ J]. Nucleic Acids Res ,2000, 28(19) :3752-3761.
  • 5Solinas A, Brown LJ, Mckeen C, et al. Duplex scorpion primers in SNP analysis and FRET applications [ J ]. Nucleic Acids Res, 2001, 29(20) :E96.
  • 6Xu H, Sha MY, Wong EY, et al. Multiplexed SNP genotyping using the Qbead system: a quantum dot-encoded microsphere-based assay [ J ]. Nucleic Acids Res,2003,31 : E4.
  • 7Vossen RH, Aten E, Roose A, et al. High-resolution melting analy- sis (HRMA) : more than just sequence -ariant screening [ J]. Hum Murat, 2009, 30(6):860-866.
  • 8Cortes A, Brown MA. Promise and pitfalls of the Immunochip [ J ]. Arthritis Res Ther, 2011,13 ( 1 ) : 101.
  • 9张素华,李莉,李成涛,赵书民.TaqMan探针技术用于X-SNP位点的分型[J].法医学杂志,2010,26(1):22-25. 被引量:16
  • 10Yokota T, Shibata N, Ura T, et al. Cyclea-e polymerase chain reac- tion method is practically applicable for V-Ki-ras2 Kirsten rat sarcoma -iral oncogene homolog (KRAS)/V-raf murine sarcoma -iral onco- gene homolog BI (BRAF) genotyping in colorectal cancer [ J ]. Transl Res, 2010, 156(2) :98-105.

二级参考文献60

  • 1张小燕,左明雪,张占军,王忠,李瑶.用基因芯片检测单核苷酸多态性反应原理[J].中国生物工程杂志,2005,25(11):52-56. 被引量:11
  • 2王娟.人类基因组SNPs的研究现状及应用前景[J].生命科学,2006,18(4):397-401. 被引量:12
  • 3汤华阳,杜卫东,张学军.焦磷酸测序技术及应用[J].医学分子生物学杂志,2007,4(3):272-275. 被引量:11
  • 4李成涛,林源,柳燕,李莉.实时DNA定量技术的应用研究[J].中国司法鉴定,2007(3):28-30. 被引量:7
  • 5Dixon LA, Murray CM, Archer EJ, et al. Validation of a 21-locus autosomal SNP multiplex for forensic identification purposes[J]. Forensic Sci Int, 2005,154 ( 1 ) : 62-77.
  • 6Li L, Li CT, Li RY, et al. SNP genotyping by multiplex amplification and microarrays assay for forensic application[J]. Forensic Sci Int,2006,162(1-3):74-79.
  • 7Tomas C, Stangegaard M, Bφrsting C, et al. Typing of 48 autosomal SNPs and amelogenin with GenPlex SNP genotyping system in forensic genetics[J]. Forensic Sci Int Genet, 2008,3 ( 1 ) : 1-6.
  • 8Desmarais D, Zhong Y, Chakraborty R, et al. Development of a highly polymorphic STR marker for identity testing purposes at the human androgen receptor gene (HUMARA) [J]. J Forensic Sci, 1998,43 (5) : 1046- 1049.
  • 9Kishida T, Wang W, Fukuda M, et al. Duplex PCR of the Y-27H39 and HPRT loci with reference to Japanese population data on the HPRT locus[J]. Nihon Hoigaku Zasshi, 1997,51 (2) : 67-69.
  • 10侯一平.法医物证学[M].第2版.北京:人民卫生出版社.2005:19.

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