原发性肾病综合征医院感染的临床特征及预防

Clinical features and prevention of primary nephrotic syndrome patients with hospital infection

目的:探讨原发性肾病综合征医院感染的临床特征及预防。方法:回顾性分析190例原发性肾病综合征的临床资料,观察其临床特征,并探讨预防对策。结果:190例原发性肾病综合征发生医院感染40例(21.05%),其中呼吸道(17例,42.50%)及泌尿道(13例,32.50%)感染最常见;26例(65.00%)致病菌培养阳性,6例(15.00%)为2种致病菌混合感染,G-杆菌16株(40.00%),G+球菌8株(20.00%),真菌8株(20.00%);医院感染患者死亡5例,平均住院时间[(37.87±11.25)d]明显高于无感染组[(17.34±6.25)d]。年龄大、病程长、侵入性操作、应用抗酸制剂、预防应用抗生素、血清白蛋白水平低是发生医院感染的相关因素。结论:原发性肾病综合征医院感染发生率高,对预后有不良影响,应针对相关危险因素采取积极措施预防和减少医院感染的发生。

Objective： To explore the clinical features and prevention of primary nephrotic syndrome patients with hospital infection.Methods： 190 cases of primary nephrotic syndrome were enrolled in retrospective analysis,clinical features were observed,and prevention countermeasures were discussed.Results： Among 40 cases（21.05%） hospital infection,respiratory tract（17 cases,42.50%） and urinary tract（13 cases,32.50%） infection were the most common infection.26 cases（65.00%） were pathogens culture positive,6 cases（15.00%） had mixed infection of the two kinds of bacterias,16（40.00%） of the G-bacteria,8（20.00%） of the G＋ Cocci,8（20.00%） of Fungi.5 cases died of hospital infection.The average length of hospitalization（37.87±11.25） days was significantly higher in hospital infection group than that of non-infected group（17.34± 6.25） days.Older,longer duration,invasive procedures,application of antacid preparations,use of antibiotics,low serum albumin levels were the related factors of hospital infection.Conclusions： Hospital infection were common in primary nephrotic syndrome patients with adverse effects to the prognosis.The hospital infection related factors should be awared and measures should be taken to reduce the rate of hospital infection.