多黏菌素E注射制剂及其临床应用

Injectable preparations and clinical applications of polymyxin E

目的:对多黏菌素E注射制剂的相关信息以及临床应用进行综述。方法:参考近年来国内外文献,对三种多黏菌素E注射制剂的基本信息、耐药性和不良反应等进行详尽的整理和讨论,对产品的临床应用进行分类和评价。结果:三种多黏菌素E注射制剂在化学结构、给药途径、给药剂量等方面都存在差异,临床医生在使用的时候尤为需要关注。除静脉注射给药外,多黏菌素E注射制剂尚有雾化吸入、鞘内或脑室内给药以及膀胱灌注等多种给药途径的应用。结论:随着多药耐药菌的出现,多黏菌素E重新获得了青春。但是,该品种仍需进一步的深入研究,同时也需要开发适应临床需求的新品种。

Objective： To review the studies on injectable preparations and clinical application of polymyxin E. Methods： Basic information about drug resistance, adverse reactions and clinical application of three injectable preparations of polymyxin E was classified and reviewed based on recent published literatures. Results： Physicians need to focus on the differences of chemical structure, route of administration and dosage in the use of three injectable preparations of polymyxin E. In addition to intravenous administration, the routes for administration of injectable preparations of polymyxin E including inhalation, intrathecal or intraventricular administration and intravesical irrigation are common. Conclusion： With the emergence of multidrug resistant bacteria, polymyxin E rejuvenated. Further studies on the new drug and the development of new preparations adapted to clinical needs are required.