2型糖尿病患者骨质疏松相关因素分析

Analysis of bone mineral density in patients with type 2 diabetes

目的:探讨2型糖尿病患者骨密度变化与身高、体重、体重指数、血糖、胰岛素等相关因素的关系。方法:采用双能X线骨密度仪进行腰椎2～4及左股骨近端骨密度测定并比较结果。结果:2型糖尿病患者的骨密度改变与血糖、糖化血红蛋白呈负相关,与胰岛细胞功能、体重、身高、体重指数呈正相关。结论:2型糖尿病患者合并骨质疏松症的发病率明显高于对照组,低体重是发生骨折的危险因素之一。对2型糖尿病患者应严格控制血糖,定期进行骨密度测定,防治骨质疏松症的发生,降低骨折的危险性。

Objective： To investigate the relationships between bone mineral density changes in the patients with type 2 diabetes complicating osteoporosis and their height, weight, body mass index, blood-glucose, glycosylated hemoglobin（HbAlc） and insulin levels. Methods： The bone mineral density in the second to fourth lumber and the proximal left femur were measured with the dual energy X BMD measuring instrument. The indicators mentioned above were compared between two groups. Results： The change of bone mineral density in the patients with type 2 diabetes was negatively correlated to the levels of blood glucose and HbAlc and positively correlated to pancreatic B cell function, weight, height and body mass. Conclusion： The incidence of osteoporosis is significantly higher in diabetes group than in control group. Lower weight is one of the risk factors resulting in fractures. Therefore, the patients with type 2 diabetes should strictly control their blood glucose levels and regularly detect their bone mineral densities so as to prevent the occurrence of osteoporosis and reduce the risk of fractures.