HE4诊断不同年龄段早期上皮性卵巢癌的临床价值

Clinical Value of HE4 in the Diagnosis of Different Ages Early Epithelial Ovarian Cancer

目的观察人附睾蛋白4对不同年龄段上皮性卵巢癌早期诊断的临床价值。方法术前采用ELISA法及E-CLIA法分别检测上皮性卵巢癌组70例、卵巢良性肿瘤组167例及健康对照组50例妇女血清样本中HE4及CA125浓度,分析HE4在不同年龄阶段的差异和诊断能力。结果诊断早期上皮性卵巢癌时,年龄<50岁,HE4特异性高于CA125及HE4联合CA125;年龄≥50岁,HE4联合CA125特异性高于HE4及CA125。结论 HE4能够提高早期上皮性卵巢癌诊断的准确率,但在老年人群中需联合CA125提高诊断能力。

Objective To observe the clinical value of HE4 at different ages in the chnical value in the early diagnosis of epithelial ovarian cancer. Methods 70 cases of patients with epithelial ovarian cancer,167 cases of benign ovarian tumors and concentration of HE4 and CA125 in serum sample form 50 healthy controls were tested to analyze the difference of HE4 in different age and diagnosis ability. Results The diagnosis of early epithelial ovarian cancer, age〈50 years old, HE4 sensibility is higher than that of CA125 combined with CA125 and HE4; 50 years of age or older, HE4 combined with CA125 sensibility is higher than that of HE4 and CA125.Conclusions HE4 can improve the accuracy of early epithelial ovarian cancer diagnosis, but should be combined with CA125 in the el- derly population.