TGF-α和PTEN在非小细胞肺癌中的表达及意义

Expressions and Significance of TGF- α and PTEN in Non-small Cell Lung Cancer

目的探讨转化生长因子-α和磷酸酶基因在非小细胞肺癌中的表达及其与临床病理特征的关系。方法采用免疫组化方法检测转化生长因子-α和磷酸酶基因在79例非小细胞肺癌组织、11例正常肺组织中的表达情况,并分析两者相关性及其与临床病理特征的关系。结果转化生长因子-α在非小细胞肺癌组织及正常肺组织中的阳性率分别为70.9%和18.2%,两者比较具有显著性差异(P﹤0.05);磷酸酶基因在非小细胞肺癌组织及正常肺组织中的阳性率分别为36.7%和72.7%,两者比较具有显著性差异(P﹤0.05)。在非小细胞肺癌中,转化生长因子-α的高表达和磷酸酶基因的低表达均与淋巴结转移、分化程度密切相关(P﹤0.05)。转化生长因子-α与磷酸酶基因两者表达呈负相关(P﹤0.05)。结论在非小细胞肺癌中,转化生长因子-α的表达显著高于正常组织,而磷酸酶基因显著失表达,表明转化生长因子-α的高表达和磷酸酶基因的缺失可能在非小细胞肺癌的发生发展中发挥着重要作用。

Objective To investigate the expression of TGF-α and PTEN in non-small cell lung cancer（NSCLC）, and explore its relationship with clinicopathologic features. Methods Using immunohistochemistry method was used to examine the expression of TGF- ct and PTEN in 79 cases of NSCLC and 11 cases of normal lung tissue.The correlation be- tween expression of TGF-α and PTEN and their relation with clinicopathological features were analyzed. Results The positive expression rate of TGF-α were 70.9% and 18.2% in non-small cell lung cancer and normal lung tissue（P〈0.05）. The positive expression rate of PTEN were36.7% and 72.7% in non-small cell lung cancer and normal lung tissue （P〈 0.05）. In NSCLC, the overexpression of TGF-α and the loss of expression of PTEN had significant correlation with the differentiation extent of cancer tissue, metastasis of lymph nodes （P〈0.05）. Conclusion The overexpression of TGF-α and the loss of expression of PTEN may play important role in occurrrence and development of NSCL.