摘要
目的探讨慢性乙型肝炎患者肝纤维化程度与门静脉、肝中静脉内径的相关性。方法利用B型超声对320例慢性乙型肝炎患者检测门静脉主干内径（DPV）和肝中静脉内径（HMDV），并与肝穿刺病理结果对比。结果DPV与肝纤维化程度呈正相关（r=0．384，P=0．032）；而DMHV与肝纤维化程度呈负相关（r=-0．521，P=0．015）。S4期肝纤维化的DPV和HMDV均高于S0、s1、s2、s3期的相应参数，差异有统计学意义（DPV：Z=0．334，P=0．032；DMHV：Z=0．161，P=0．015）；DPV诊断s4期的最佳值为13mm，DMHV诊断S4期的最佳值为6mm。DPV和DMHV在≥s2期时的曲线下面积分别为0．753和0．758，≥s3期时的曲线下面积分别为0．795和0．802；s4期时的曲线下面积分别为0．797和0．828。DPV联合HMDV诊断肝纤维化s4期的ROC曲线下面积为0．866，均高于DPV和HMDV。结论超声检测指标DPV和HMDV同慢性乙型肝炎肝纤维化程度相关性较佳，DPV联合HMDV对诊断早期肝硬化意义重大。
Objective To investigate the correlation between the stage of hepatic fibrosis and the diameter of portal vein （DPV） and middle hepatic vein （DMHV） in patients with chronic hepatitis B. Methods 320 patients with chronic hepatitis B were evaluated by uhrasonography. The DPV and DMHV were measured, and their correlation with the degree of hepatic fibrosis was analyzed after liver biopsy. Results DPV was positively related with the degree of hepatic fibrosis （r = 0. 384, P = 0. 032 ）, while DMHV was negatively related with the degree of hepatic fibrosis （r = -0. 521 ,P =0. 015）. The DPV and HMDV in S4 were bigger than those of SO,S1 ,S2 and S3,and statistical differences existed among them （ DPV ： z = 0. 334, P = 0. 032 ; DMH ： z = 0.161, P = 0.01 5 ）. The best value of $4 diag- nosing by DPV was 13ram. The best value of S4 diagnosing by DMHV was 6mm. The area under the curve of ROC for DPV and DMHV in ≥S2 was 0. 753 and 0. 758 respectively. It in ≥S3 was 0.795 and 0.802 respectively. It in ≥S4 was 0. 797 and 0. 828 respectively. The area under the curve of ROC for combination of DPV and HMDV was 0. 866, which was higher than that of DPV and HMDV. Conclusion There is a good correlation between DPV, DMHV and the stage of hepatic fibrosis in patients with chronic hepatitis B. Combination of DPV and HMDV has clinical significance for diagnosing early hepatic fibrosis.
出处
《中国基层医药》
CAS
2013年第13期1956-1958,共3页
Chinese Journal of Primary Medicine and Pharmacy
关键词
肝硬化
超声检查
门静脉
肝静脉
Liver cirrhosis
Uhrasonography
Portal vein
Hepatic veins
