ZIP4蛋白在胃癌中的表达及其临床意义

Expression of ZIP4 Protein in Gastric Cancer and Its Clinical Significance

[目的]研究ZIP4蛋白在胃癌中的表达并分析其临床意义。[方法]免疫组化检测70例手术切除胃癌组织及相应癌旁组织标本中ZIP4的表达,并分析其与患者临床病理特征及预后的关系。[结果]胃癌及癌旁组织中ZIP4阳性表达率分别为52.9%(37/70)及92.9%(65/70)。与癌旁组织相比,68.6%(48/70)病人的胃癌组织中ZIP4表达明显下降;ZIP4的表达水平与患者的性别、年龄、肿瘤大小、部位、浸润深度、淋巴结转移均无相关性(P>0.05),而与肿瘤的Lauren’s分型、TNM分期明显有关(P<0.05);单因素及多因素分析均显示,肿瘤侵犯深度、淋巴结转移、Lauren’s分型、TNM分期及ZIP4表达水平是影响胃癌预后的独立危险因素(P<0.05),ZIP4低表达组患者5年生存率明显降低。[结论]ZIP4表达水平与胃癌Lauren’s分型、临床分期及预后密切相关,可作为判断胃癌生物学行为和预后的重要参考指标。

Purpose To investigate the expression of ZIP4 protein in gastric cancer and its clinical significance. Methods Expressions of ZIP4 protein in cancer tissues and cancer adjacent tissues were detected immunohistochemically in 70 cases with gastric cancer,and their relationships with clinicopathological features and prognosis were analyzed. Results The positive rates of ZIP4 expression in gastric cancer tissues and cancer adjacent tissues were 52.9%（37/70） and 92.9%（65/70） respectively. Lower expression of ZIP4 in gastric cancer tissue than that in cancer adjacent tissues was found in 68.6%（48/70） of patients. Expression of ZIP4 did not correlate to age,gender,tumor size,location,invasive depth or lymph nodes metastasis （P0.05）,but correlated to the Lauren’s type and TNM staging （P0.05）. Both univariate or multivariate analysis revealed that invasive depth,lymph nodes metastasis,Lauren’s type,TNM stage and ZIP4 expression were independent predictors of prognosis（P0.05）. Patients with lower ZIP4 expression resulted worse 5-year survival. Conclusion Expression of ZIP4 in gastric cancer relates to the Lauren’s type, clinical stage and prognosis,and it might be useful to evaluate the biological behavior and prognosis for gastric cancer.