圆瓣姜花的化学成分研究

Studies on Chemical Constituents of the Rhizomes of Hedychium forrestii Diels

目的对圆瓣姜花(Hedychium forrestii Diels.)的根茎部分进行化学成分研究。方法对圆瓣姜花根茎的95%乙醇提取物经乙酸乙酯萃取。乙酸乙酯萃取物经硅胶、十八烷基硅烷键合相(ODS)、葡聚糖醚凝胶SephadexLH-20等色谱方法进行分离纯化,并运用MS、NMR等波谱方法鉴定化合物的结构。结果从圆瓣姜花中分离鉴定了5个化合物,分别为:5-hydroxy-3,7,4′-trimethoxyflavone(I),3,5-dihydroxy-7,4′-dimethoxyflavone(II),5-hydroxy-7-(4-hydroxy-3-methoxyphenyl)-1-(4-hydroxy-phenyl)-3-heptanone(III),(5R)-5-hydroxy-1-(3,4-dihydroxyphenyl)-7-(4-hydroxy-3-methoxyphenyl)-3-heptanone(IV),stigmast-4-en-3-one(V)。结论 5个化合物均为从该植物中首次分离得到。

Objective To research the chemical constitutes isolated from the rhizomes of Hedychium forrestii Diels. Methods The rhizomes of H. forrestii Diels. were extracted with 95% ethanol,which was suspended in water and then extracted with ethyl acetate. The ethyl acetate extract was extensively separated over chromatographic methods,including silica gel,octadecylsilane （ODS）,and Sephadex LH-20. These compounds were elucidated by extensive spectroscopic analysis （MS, NMR,etc. ）. Results five compounds,[5-hydroxy-3,7,4＇-trimethoxyflavone （Ⅰ）,3,5-dihydroxy-7,4＇-dimethoxyflavone （Ⅱ）,5-hydroxy-7-（4-hydroxy-3- methoxyphenyl）-1-（4-hydroxy-phenyl）-3-heptanone （Ⅲ）, （SR）-5-hydroxy-1-（3,4-dihydroxyphenyl）-7-（4-hydroxy-3- methoxyphenyl）-3-heptanone （Ⅳ）,stigmast-4-en-3-one （Ⅴ）. ] were isolated and identified. Conclusion Five compounds were all isolated from Hedychium forrestii for the first time.