中药正性影响骨髓间充质干细胞成骨分化及机制的进展

Progressive Studies on Effects and Mechanisms of Traditional Chinese Medicines on Osteogenic Differentiation of Bone Mesenchymal Stem Cells

骨髓间充质干细胞(Bone marrow mesenchymal stem cells,BMSCs)具有多能分化能力,并具有易于获得、低免疫排斥性等特点,现今已成为研究热点之一,其已在中药研究中有广泛应用,尤其是在促其成骨相关研究中,中药可有效促进BMSCs成骨,提高碱性磷酸酶、骨钙素等成骨标志因子的表达,同时研究者对中药促成骨机制也有深入研究。本文就中药正性影响BMSCs成骨分化的研究进行总结。

Bone marrow mesenchymal stem cells （BMSCs）have an active ability of multidifferentiation. Because of some advanced characteristics including sampling convenience,no immune rejection,it becomes a research hot spots,and now widely used in Chinese medicine researches,especially in studies of osteogenic differentiation induced by Chinese medicine. Evidences show that the traditional Chinese medicines can induce BMSCs differentiate into osteoblast,and increase expression of specific markers of osteogenesis such as alkaline phosphatase and osteocalcin. The mechanisms are also studied by researchers,reported different signal path ways are activated. In this paper,the studies of traditional Chinese medicines on osteogenic differentiation of BMSCs are summarized.