探讨血清胱抑素C、β_2-微球蛋白与ABO溶血病致肾损伤的关系

To investigate the relationships between serum cystatin C, serum β_2-microglobulin and ABO hemolytic direar of new bown

目的探讨血清胱抑素C(CysC)、β2-微球蛋白(β2-MG)与ABO溶血病(ABOHDN)致肾损伤的关系。方法对40例ABO溶血病和20例正常新生儿的血清胱抑素C、β2-微球蛋白、尿素氮(BUN)、肌酐(Ccr)进行测定。结果由表中可见ABO溶血病组血清胱抑素C、β2-微球蛋白及总胆红素明显高于对照组,而血尿氮及肌酐两组相比差异无统计学意义。结论血清胱抑素C、β2-微球蛋白对ABO溶血病肾损害的早期诊断、治疗及防止其进一步发展有重要临床意义。

Objective To investigate the relationships between serum cystatin C（Cys C）, serum β2-microglobulin（β2-MG） and ABO hemolytic direar of new born.Methods Collect 40 ABO hemolytic direar of new born and 20 normal infants,and test Cys C, β2-MG,blood urea nitrogen（BUN） and serum creatinine（Ccr） Results From the table,we can find that the potency of Cys C, β2-MG, total bilirubin in the group of ABO hemolytic direar of new born was significant,but the difference of the level of BUN and Ccr was not statistically significant between two groups.Conclusion The level of Cys C and β2-MG were very important clinical significance in early diagnosis,treatment and prevent the further development of the ABO hemolytic direar of new born to kidney damage.