小儿原发性肾病综合征的血清甲状腺激素水平临床分析

Clinical analysis of serum thyroid hormone levels in children with primary nephrotic syndrome

目的研究小儿原发性肾病综合征同血清甲状腺激素水平间的关系。方法选择本院64例原发性肾病综合征患儿,作观察组,同期入院体检的64例同龄健康儿童作对照组,检测两组儿童的血清甲状腺激素水平和蛋白水平,对比分析检测结果。结果观察组患儿的血清游离三碘甲腺原氨酸(FT3)和血清游离甲状腺素(FT4)水平均要明显低于对照组,促甲状腺激素(TSH)水平明显高于对照组,上述差异具有统计学意义(P<0.05);经直线相关分析,FT3和FT4同血清白蛋白水平呈正相关,同24h尿蛋白呈负相关,TSH同血清蛋白水平无显著相关性。结论 FT3、FT4同血清蛋白有着密切的联系,甲状腺激素水平的检测利于原发性肾病综合征的临床治疗。

Objective To study the relationship between children with primary nephrotic syndrome and serum thyroid hormone levels. Methods A total of 64 patients with primary nephrotic syndrome in children, as the observation group, 64 cases of hospitalized medical healthy children as control group, detect the level of serum thyroid hormone in two groups of children and the protein level, detection and analysis of results. Results Three iodine THYRONINE free serum observation group （FT3） and serum free thyroxine （FT4） levels were significantly lower than those in the control group, the thyroid stimulating hormone （TSH） levels were significantly higher than that of control group, the difference was statistically significant （P 0.05）; the straight line correlation analysis, FT3 and FT4 and serum albumin levels were positively correlated with 24 h, urinary protein was negatively correlated with the serum protein level, TSH had no significant correlation. Conclusion FT3, FT4 are closely linked with the serum protein, detection of thyroid hormone level for clinical treatment of primary nephrotic syndrome.