摘要
目的探讨应用聚乙二醇干扰素联合利巴韦林抗病毒治疗慢性丙型肝炎，在治疗结束后，观察患者复发的影响因素及复发时间规律。方法对92例应用聚乙二醇干扰素联合利巴韦林抗病毒治疗的慢性丙型肝炎患者开展流行病学调查，通过病例对照研究，分析影响复发的因素。结果92例患者中有81例获得持续病毒学应答，11例复发。其中持续应答组的快速病毒学应答率、完全早期病毒学应答率明显高于复发组，且差异有统计学意义（快速病毒学应答率P〈0．05；完全早期病毒学应答率P〈0．001）。11例复发者复发发生在停药后24周内，8例发生在12周内。结论聚乙二醇干扰素联合利巴韦林治疗慢性丙型肝炎早出现病毒学应答，其复发率会越低。
Objective To evaluate the influencing factors of chronic hepatitis C relatpse treated with pegylated interferon alpha-2a and ribavirin in post-treatment, and study on relatpse time. Methods 92 chronic hepatitis C patients treated with pegylated interferon alpha-2a and ribavirin relapsed in post-treat- ment. A retrospective study was designed to analyze the influencing factors of chronic hepatitis C relatpse. Results 81 patients receives the sustained virological response（ SVR）, 11 patients relapsed. The rapid vir- ological response and complete early virological response of SVR patients were significantly higher than re- lapsed patients（ P 〈 0. 05 ; P 〈 0. 001 ）. 11 relapsed patients oecured within 24 weeks after stopped therapy, 8 relapsed patients occured within 12 weeks. Conclusions The sooner of virus response to pgylated inter- feron alpha- 2a plus ribavirin therapy , the lower of the relapse rate.
出处
《国际病毒学杂志》
2013年第3期115-117,共3页
International Journal of Virology
