射频超声技术评价糖耐量减低患者颈动脉弹性的临床研究

Evaluation of carotid artery elasticity in patients with impaired glucose tolerance by ultrasound radio-frequency data technique

目的:探讨射频超声技术在糖耐量减低患者颈动脉弹性中的临床应用价值。方法:选取58例糖耐量减低的人群和39例健康者作为研究对象。利用射频超声技术对颈总动脉行超声检查,记录颈动脉弹性参数,包括血管内中膜厚度(IMT)、动脉管壁的扩张度(e)、顺应性系数(CC)、僵硬度系数(β)、脉搏波传导速度(PWV),运用统计学方法比较各参数的差异并对其进行相关性分析。结果:①与正常对照组相比,IGT组的体质指数(BMI)、餐后2 h血糖(2-hPG)、总胆固醇(TC)、甘油三酯(TG)明显高于对照组,差异有统计学意义(P<0.05);②IGT组的IMT、β、PWV均明显增高,颈动脉弹性系数e、CC均明显降低(P<0.05),差异有统计学意义;③应用Pearson相关分析发现病例组颈动脉IMT与PWV、年龄、β呈正相关(r=0.290～0.661,P均<0.05);PWV与年龄、IMT、β呈正相关(r=0.441～0.933,P均<0.05),两者均与弹性系数e及CC呈负相关(P<0.05)。结论:射频超声技术可用于评价糖耐量减低患者的颈动脉血管弹性变化,从而间接判断早期动脉硬化。

Objective：To explore the value of ultrasound radio-frequency（RF） data technique in assessing carotid artery elasticity in patients with impaired glucose tolerance.Methods：In this study,58 objects in IGT group and 39 objects in the control group were included.All patients received ultrasound RF-data technique examination on the carotid artery.The following elastic parameters：intima-media thickness（IMT）,vascular expansibility（e）,compliance coefficient（CC）,stiffness parameter（β）,pulse wave velocity（PWV） were obtained.The correlation of them and the differences among the parameters were analyzed.Results：①Compared with normal control group,BMI,2-hPG,TC,TG of IGT group were significantly higher in IGT group（P〈0.05）;② IMT,β,PWV of IGT group were significantly higher,e,CC were significantly lower in IGT group（P〈0.05）;③ In the IGT group,through Pearson correlation analysis,IMT was correlated positively with PWV,age and β（r = 0.290～0.661,all P〈0.05）,and PWV was correlated positively with age,IMT and β（r = 0.441～0.933,all P〈0.05）.IMT and PWV were correlated negatively with e,CC（P〈0.05）.Conclusion：Ultrasound radio-frequency（RF） data technique can evaluate carotid artery elasticity in patients with impaired glucose tolerance,and it should be indicators in the diagnosis of early atherosclerosis.