精神分裂症伴与不伴糖尿病患者认知功能和生活质量比较

Comparision of cognitive functions and life quality in schizophrenia with or without diabetes

目的比较伴与不伴糖尿病的精神分裂患者认知功能和生活质量的差别。方法对我院诊治的128例精神分裂症患者的临床资料进行回顾性分析,其中单纯精神分裂症未合并糖代谢紊乱68例,伴2型糖尿病的精神分裂症60例。采用阳性与阴性症状量表(PANSS)、精神分裂症认知功能成套测验共识版(MCCB)及健康状况问卷(SF-36)评估患者病情、认知功能及生活质量。结果伴糖尿病精神分裂症组PANSS阴性症状评分及总分显著高于单纯精神分裂症组(P<0.05);2组言语记忆、语义流畅、视觉记忆、迷宫、持续操作、数字序列及符号编码评分比较差异有统计学意义(P<0.05);伴糖尿病精神分裂症组SF-36表中躯体疼痛、生理功能、一般健康和精神健康评分显著低于单纯精神分裂症组(P<0.05)。结论伴糖尿病的精神分裂患者认知功能和生活质量损害更为严重。

Objective To compare the cognitive functions and life quality in schizophrenia with or without diabetes.Methods The data of 128schizophrenia patients were retrospectively analyzed including 60patients with diabetes and 68 patients without diabetes.PANSS,MCCB and SF-36scales were used to evaluate the disease condition,cognitive functions and life quality.Results PANSS negative score and total score in schizophrenia with diabetes were much higher than these in the patients without diabetes（P0.05）.The MCCB of two groups had a significant difference（P0.05）.Body pain,physiological function,general health and mental health of SF-36in schizophrenia with diabetes were lower than these in the patients without diabetes（P0.05）.Conclusion The cognitive functions and life quality in schizophrenia with diabetes are severer than these in the patients without diabetes.