吉林省新生儿先天性甲状腺功能减低症筛查切值研究

A research on cut off value of thyroid stimulating hormone for newborn congenital hypothyroidism screening in Jilin province

目的建立吉林省新生儿先天性甲状腺功能减低症(CH)筛查TSH实验切值。方法新生儿出生72 h后,并充分哺乳,采集足跟血滴于专用滤纸上,采用时间分辨荧光免疫分析方法,检测滤纸干血片TSH浓度。结果测定新生儿足跟血TSH共计30 000例,确定本实验室新生儿TSH切值为9.0 mIU/L。结论 TSH切值为9.0 mIU/L是适合吉林省实际情况的。TSH切值的确定为吉林省今后开展大规模的新生儿CH筛查提供了依据。

Objective To determine cut off value of thyroid stimulating hormone （TSH） for screening of congenital hypothyroid- ism （CH） of newborn in Jilin province. Methods The foot blood samples were obtained at 72 hours after birth and s^ficient breast feeding to detect the content of TSH. Results 30 000 neonates were screened, the cut off value of TSH for screening of congenital hypothyroidism of newborn in Jilin was 9.0 mIU/L. Conclusion The TSH cut off value was adjusted to 9.0 mIU/L. The determination of TSH cut off value provided a basis for screening of congenital hypothyroidism among the newborns in Jilin.