H7亚型禽流感病毒感染人的组织嗜性分析

The major determinants of tissue tropism of H7 subtype avian influenza A viruses associated with human infections

截至2013年5月1日,我国大陆地区共报告确诊人感染H7N9禽流感病毒病例127例,其中死亡26人,公共卫生安全受到严重威胁.历史上,H7亚型禽流感病毒曾多次感染人类.早期报告的人感染H7亚型禽流感病毒主要表现为结膜炎等温和疾病,而此次H7N9禽流感病毒感染却表现为严重的急性呼吸道疾病,呈现出不同寻常的感染特征.本文对H7亚型禽流感病毒感染人组织嗜性特征及其决定因素进行了解析,以期为此次H7N9疫情的科学防控提供依据.

The sudden emerged H7N9 influenza A virus has infected 127 persons including 26 deaths in China's Mainland by May 1, 2013, posing a great threat on public health. Human infections with H7 subtype avian virus have been reported worldwide. However, most cases commonly characterized by conjunctivitis are mild. Currently, human infected with the novel H7N9 virus developed severe lower respiratory illness that is quite unique from previous H7 subtype viral infections. The pathogenicity and tissue tropism of H7 subtype avian influenza A viruses are discussed in this manuscript.