6-氨基苯并噻唑环类衍生物的合成方法探讨

Synthesis of 6-Amino-benzothiazole ring derivatives

目的合成6-氨基苯并噻唑环类衍生物。方法以2-氨基-5-硝基苯硫醇为原料,通过环化、氨解、酰基化和硝基还原反应完成反应路线。结果合成了五个新型的6-氨基苯并噻唑环类衍生物,其结构经过1H-NMR表征。结论探索的反应路线方法可靠,操作简便。

Objective To synthesize 6-amino-benzothiazole ring derivatives. Methods With 2-amino-5-nitrothiophenol as raw material, synthetic strategy was completed by cyclization, ammonolysis, acylation and the reduction of nitro. Results Five novel 6-amino-henzethiazole ring derivatives were synthesized. The structures were characterized by 1H-NMR. Conclusions The method of the synthetic strategy is reliable and the operation