两种硬化治疗方法对面颈部巨大静脉畸形的疗效比较

Comparison of clinical efficiency of two sclerotherapies for huge venous malformation in face and neck regions

目的比较生物胶联合OK-432和平阳霉素与区室化联合OK-432和平阳霉素两种硬化治疗方法对面颈部巨大静脉畸形的临床疗效。方法选择63例面颈部巨大静脉畸形患者,随机分为A、B两组,A组30例,B组33例。A组以生物胶联合OK-432和平阳霉素经皮共同注射;B组对病灶行区室化后,经皮注射OK-432和平阳霉素。两组均经气管插管全麻下进行,相隔1个月注射1次,连续注射1～5次。比较2组的疗效和并发症。结果随诊6～12个月,平均8.2个月。A组平均治疗时间1.5个月,平均治疗次数2.5次,20例治愈,6例显效,2例有效,2例部分有效,没有无效病例;治愈率为66.67%,总有效率为100%。B组平均治疗时间3.5个月,平均治疗次数4.3次,13例治愈,9例显效,9例有效,2例部分有效,没有无效病例,治愈率为33.33%,总有效率为100%。A、B两组治愈率差异有统计学意义(χ2=21.01,P<0.01);A、B两组患者均有局部肿胀,无严重并发症出现,差异无统计学意义(χ2=1.56,P>0.05)。结论生物胶联合OK-432和平阳霉素经皮硬化术治疗面颈部巨大静脉畸形疗程短、疗效良好、安全、可靠。

Objective To compare the clinical efficiency of biogel combined with OK-432 and pingyangmyein with compartmentalization combined with 0K-432 and pingyangmyein for huge venous mallormation in lace and neck reginns. Methods Sixty-three cases with huge venous mallormation in face and neck regions were selected. All the patients were randomly divided into two groups： 30 eases in group A and 33 eases in group B. Palients in group A were injeeted with hiogel combined with OK-432 and pingyangmyein while pereutaneous selerntherapy af OK-432 and pingyangmyein were applied followed by compartmentalization in group B. All the patienls were given injections under tracheal intubation anesthesia one time a month for one to five times. The effieaeies and complications were compared between the two groups. Results The fnllowed up period ranged from 6 to 12 moths （mean, 8.2 months）. In group A, 20 cases were eared, 6 eases markedly effective, 2 eases effective and 2 eases parlially efteetive, no inwdid eases. The cure rate was 66.67%, and the total effective rate was 100%. The average treatment time was 1.5 months, and the average times of treatments were 2.5. In group B, 13 eases were cured, 9 cases markedly effective, 9 eases effective and 2 eases partially effeetive, no invalid eases. The cure rate was 43.33% , and the total effective rate was 100% The average treatment time was 3.5 months, and the average times of treatments were 4.3. The cure rate of two groups was statistically significantly different （X2 =21.01 , P 〈0 01 ）. Complications of two groups included local swelling, fever and so on, and no serious complications. There was no statistical significance. Conclusion The way that applying biogel combined with OK-432 and pingyangjnyein pereutaneous selerotherapy for huge venous malfiwmation in face and neck regions showed short course, good effect, and is safe and reliable.