体重异常老年男性血清前列腺特异性抗原与生长激素水平观察及相关性分析

Relationship between Serum Total Prostate-specific Antigen and Serum Growth Hormone in Men Aged over 60 years with Abnormal Weight

目的观察与分析体重异常老年男性血清前列腺特异性抗原(T-PSA)与生长激素(GH)水平及影响因素。方法以2009年1月-2012年6月,血清GH<5 ng/mL、血清T-PSA<4.5 ng/mL的老年男性共296例作为观察对象,依据体质量指数分为低体重组、正常体重组、超重组及肥胖组。依据年龄分为60～64、65～69、70～74及≥75岁四组。测定296例入选对象的血清T-PSA及GH并进行分析。结果随着年龄增长,血清T-PSA、GH渐增高。≥75岁年龄组血清T-PSA高于其他三组,差异无统计学意义(P>0.05)。≥75岁年龄组血清GH高于其他三组,差异有统计学意义(P<0.01)。超重组及肥胖组血清T-PSA低于正常体重组,差异有统计学意义(P<0.01)。低体重组血清T-PSA稍低于正常体重组,差异无统计学意义(P>0.05)。肥胖组血清GH低于超重及正常体重组,差异无统计学意义(P>0.05)。低体重组血清GH低于正常体重组,差异无统计学意义(P>0.05)。单因素相关分析显示血清T-PSA与年龄、GH正相关;与BMI负相关;与收缩压(SBP)、舒张压(DBP)、空腹血糖(FPG)及血脂不相关。血清GH与年龄、T-PSA、SBP、DBP正相关;与BMI、FPG及血脂不相关。校正年龄、BMI后,血清T-PSA与GH仍呈正相关。结论随着年龄增长,老年男性血清T-PSA、GH渐增高。老年男性非肢端肥大症者血清T-PSA与血清GH水平及BMI有关联,血清GH水平较高者,血清T-PSA也较高;血清T-PSA与BMI负相关。

Objective To study the levels of serum prostate-specific antigen（T-PSA） and serum growth hormone（GH） in senile men with abnormal weight,and their related factors.Methods From January 2009 to June 2012,we observed 296 men over 60 years with their GH lower than 5 ng/mL and T-PSA lower than 4.5 ng/ml.Based on body mass index,we divided them into low weight group,normal group,overweight group and obese group.According to their age,the patients were divided into four groups： those aged between 60-64 years old,those between 65-69,those between 70-74,and those who were or older than 75 years old.Serum T-PSA,GH,FPG,TC,TG,HDL-C,LDL-C,SBP,DBP and BMI of all patients were determined and statistically analyzed.Results From age 60 to 75,the level of serum T-PSA and GH increased gradually.The 75 year old group had higher serum GH than 60-64,65-69,and 70-74 age groups（P〈0.01）.The serum T-PSA was the highest among four different age groups,but no statistical difference was found between 75 years old group and 60-64,65-69,70-74 years old groups（P〈0.05）.Obese men had lower serum GH than normal weight group and overweight subjects,but there was no statistical difference（P〈0.05）.Overweight and obese men had lower serum T-PSA than normal weight subjects（P〈0.01）.The low weight group had lower serum T-PSA and GH than those of the normal weight group,but no statistical difference was observed in the two groups（P〈0.05）.The serum T-PSA was positively correlated with age,serum GH,negatively correlated with BMI;No correlation with FPG,TC,TG,HDL-C,LDL-C,SBP,and DBP was found.The serum GH was positively correlated with age,serum T-PSA,SBP,DBP,and was not correlated with BMI,FPG,TC,TG,HDL-C and LDL-C.After adjusting for age and BMI,a positive relationship was still observed between serum T-PSA and GH.Conclusions Our data suggest that the level of serum T-PSA and GH rises gradually along with increasing age in elder men.There is a positive correlation between serum T-PSA and serum GH in senile men.The serum T-PSA appears to be decreasing,along with increasing weight.