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硝基咪唑类肿瘤乏氧细胞显影剂化学结构与构效关系研究新进展 被引量：2

New Progress of Chemical Structure and Structure-Activity Relationship On Nitroimidazole As Hypoxic Celles Developer
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摘要 硝基咪唑类肿瘤乏氧细胞显影剂是目前国内外研究得较为成熟并且具有发展前景的一类用于肿瘤治疗的药物。本文对近年来几类具有代表性的硝基咪唑类化合物的化学结构、生物学活性、作用机制进行综述,并对显影剂今后的应用前景进行了展望。 Nitroimidazole is widely and deeply researched as hypoxic celles developer in China and abroad at present.This paper reviews their structure,biological activities,mechanisms,and structure-activity relationships,and the application foreground is prospected in the future for the developer.
作者 黄静 冯灏 马梦林 刘治国
机构地区 西华大学物理与化学学院
出处 《西华大学学报（自然科学版）》 CAS 2013年第4期45-52,共8页 Journal of Xihua University:Natural Science Edition
基金 教育部2013年中央高校基本科研业务费专项(XDJK2013C120) 四川省科技厅应用基础研究项目(2013JY0090) 西华大学人才引进项目(Z1223321)
关键词 硝基咪唑 乏氧细胞显影剂 化学结构 生物学活性 作用机制 Nitroimidazole hypoxic celles developer chemical structure biological activity mechanism of action
分类号 TJ55 [兵器科学与技术—军事化学与烟火技术] O626.2 [理学—有机化学]
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  • 1Jason L. J. Dearling,Jason S. Lewis,Gregory E. D. Mullen,Michael T. Rae,Jamal Zweit,Philip J. Blower. Design of hypoxia-targeting radiopharmaceuticals: selective uptake of copper-64 complexes in hypoxic cells in vitro[J] 1998,European Journal of Nuclear Medicine(7):788～792

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西华大学学报（自然科学版）
2013年 第4期

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