多巴胺D1受体激动剂对中枢神经系统疾病的治疗作用及其靶点通路研究进展
摘要
DA受体根据其不同信号转导机制分为：D1样受体和D2样受体。D1样受体与Gs蛋白偶联，受刺激后能提高腺苷酸环化酶（AC）活性，升高细胞内环磷腺苷（cAMP）水平，这类受体包括D1和D52种亚型；D2样受体与Gi蛋白偶联，受刺激后能降低AC的活性，降低细胞内cAMP水平，包括D2、D3、D4受体。
出处
《临床合理用药杂志》
2013年第17期102-103,共2页
Chinese Journal of Clinical Rational Drug Use
基金
国家"十二五"重大新药创制专项"新型G蛋白偶联受体靶向药物筛选体系建立及其关键技术研究"(NO:2012ZX09504001-001)
2010年教育部"新世纪优秀人才支持计划资助"(No:NCET-10-0817)
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