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β_1-肾上腺素受体与中枢神经系统疾病相关性研究进展

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摘要 G-蛋白偶联受体（GPCRs）是一类功能最全面且最为庞大的跨膜受体家族。β-肾上腺素受体（β—adrenoceptor，β—AR）是经典的G蛋白偶联受体家族的成员，其生物学效应由经典的Gs—cAMP—PKA信号通路介导。人们对β-肾上腺素的研究主要集中于其对心力衰竭、心血管、心肌自律性和传导功能等的作用。
作者 苏冉 何玲
机构地区 中国药科大学药理教研室
出处 《临床合理用药杂志》 2013年第17期109-110,共2页 Chinese Journal of Clinical Rational Drug Use
基金 国家"十二五"重大新药创制专项--"新型G蛋白偶联受体靶向药物筛选体系建立及其关键技术研究"(NO:2012ZX09504001-001) 2010年教育部"新世纪优秀人才支持计划资助"(No:NCET-10-0817)
关键词 Β1-肾上腺素受体 中枢神经系统 激动剂 拮抗剂
分类号 R741 [医药卫生—神经病学与精神病学]
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参考文献14

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临床合理用药杂志
2013年 第17期

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